UC Davis MIND Institute Research Finds Autism Early Intervention Found to Normalize Brain Activity in Children as Young as 18 months

Sacramento, Calif. (PRWEB) October 26, 2012

An intensive early intervention therapy that is effective for improving cognition and language skills among very young children with autism also normalizes their brain activity, decreases their autism symptoms and improves their social skills, a nationwide study has found. The researchers said the study is the first to demonstrate that an autism early intervention program can normalize brain activity.

“We know that infant brains are quite malleable and previously demonstrated that this therapy capitalizes on the potential of learning that an infant brain has in order to limit autism’s deleterious effects,” said study author Sally Rogers, professor of psychiatry and behavioral sciences and a researcher with the UC Davis MIND Institute.

“The findings on improved behavioral outcomes and the ability to normalize brain activity associated with social activities signify that there is tremendous potential for the brains of children with autism to develop and grow more normally,” Rogers said.

Published online today in the Journal of the American Academy of Child & Adolescent Psychiatry, the randomized, case-controlled, multi-centered study titled “Early behavioral intervention is associated with normalized brain activity in young children with autism,” found that the children who received the intervention exhibited greater brain activation when viewing faces rather than objects, a response that was typical of the normal children in the study, and the opposite of the children with autism who received other intervention.

The U.S. Centers for Disease Control and Prevention estimates that 1 in 88 children born today will be diagnosed with autism spectrum disorder. Hallmarks of the neurodevelopmental condition include persistent deficits in social communication and relatedness, and repetitive or restrictive patterns of interest that appear in early childhood and impair everyday functioning.

Named the Early Start Denver Model (ESDM), the intervention method was developed by Rogers and Geraldine Dawson, chief science officer of the research and advocacy organization Autism Speaks. The therapy fuses a play-based, developmental, relationship-based approach and the teaching methods of applied behavioral analysis.

“This may be the first demonstration that a behavioral intervention for autism is associated with changes in brain function as well as positive changes in behavior,” said Thomas R. Insel, director of the National Institute of Mental Health, which funded the study. “By studying changes in the neural response to faces, Dawson and her colleagues have identified a new target and a potential biomarker that can guide treatment development.”

For the present study, the researchers recruited 48 diverse male and female children diagnosed with autism between 18 and 30 months in Sacramento, Calif., and in Seattle, as well as typically developing case controls. The ratio of male-to-female participants was more than 3-to-1. Autism is five times more common among boys than girls.

Approximately half of the children with autism were randomly assigned to receive the ESDM intervention for over two years. The participants received ESDM therapy for 20 hours each week, and their parents also were trained to deliver the treatment, a core feature of the intervention. The other participants with autism received similar amounts of various community-based interventions as well as evaluations, referrals, resource manuals and other reading materials.

At the study’s conclusion, the participants’ brain activity was assessed using electroencephalograms (EEGs) that measured brain activation while viewing social stimuli — faces — and non-social stimuli — toys. Earlier studies have found that typical infants and young children show increased brain activity when viewing social stimuli rather than objects, while children with autism show the opposite pattern.

Twice as many of the children who received the ESDM intervention showed greater brain activation when viewing faces rather than when viewing objects — a demonstration of normalized brain activity. Eleven of the 15 children who received the ESDM intervention, 73 percent, showed more brain activation when viewing faces than toys. Similarly, 12 of the 17 typically developing children, or 71 percent, showed the same pattern. But the majority — 64 percent — of the recipients of the community intervention showed the opposite, “autistic” pattern, i.e., greater response to toys than faces. Only 5 percent showed the brain activation of typical children.

Further, the children receiving ESDM who had greater brain activity while viewing faces also had fewer social-pragmatic problems and improved social communication, including the ability to initiate interactions, make eye contact and imitate others, said MIND Institute researcher Rogers. Use of the ESDM intervention has been shown to improve cognition, language and daily living skills. A study published in 2009 found that ESDM recipients showed more than three times as much gain in IQ and language than the recipients of community interventions.

“This is the first case-controlled study of an intensive early intervention that demonstrates both improvement of social skills and normalized brain activity resulting from intensive early intervention therapy,” said Dawson, the study’s lead author and professor of psychiatry at the University of North Carolina, Chapel Hill. “Given that the American Academy of Pediatrics recommends that all 18- and 24-month-old children be screened for autism, it is vital that we have effective therapies available for young children as soon as they are diagnosed.”

“For the first time,” Dawson continued, “parents and practitioners have evidence that early intervention can alter the course of brain and behavioral development in young children. It is crucial that all children with autism have access to early intervention which can promote the most positive long-term outcomes.”

Rogers, Dawson and Laurie J. Vismara, also a researcher with the MIND Institute, have authored two books on the intervention. One for professionals is titled “Early Start Denver Model for Young Children with Autism: Promoting Language, Learning, and Engagement” and one for parents titled “An Early Start for Your Child with Autism: Using Everyday Activities to Help Kids Connect, Communicate, and Learn.”

The ESDM intervention is available in Sacramento through the MIND Institute clinic and in a number of locations throughout the U.S. and other nations. Training in delivering the ESDM method is provided through the MIND Institute and the University of Washington.

Other study authors include Emily J.H. Jones, Kaitlin Venema, Rachel Lowy, Susan Faja, Dana Kamara, Michale Murias, Jessica Greenson, Jamie Winter, Milani Smith and Sara J. Webb, all of the University of Washington, and Kristen Merkle of Vanderbilt University.

The study was funded by a grant from the National Institute of Mental Health and by a postdoctoral fellowship to Jones from Autism Speaks.

Autism Speaks is the world’s leading autism science and advocacy organization. It is dedicated to funding research into the causes, prevention, treatments and a cure for autism; increasing awareness of autism spectrum disorders; and advocating for the needs of individuals with autism and their families.

At the UC Davis MIND Institute, world-renowned scientists engage in collaborative, interdisciplinary research to find the causes of and develop treatments and cures for autism, attention-deficit/hyperactivity disorder (ADHD), fragile X syndrome, 22q11.2 deletion syndrome, Down syndrome and other neurodevelopmental disorders. For more information, visit mindinstitute.ucdavis.edu

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    Flight Simulator Games, News and More Detailed at iFlightSimulatorGames.com

    Phoenix, AZ (PRWEB) October 28, 2012

    For many people, flying is liberating and challenging. Individuals who dream of flying do chase their dreams and become professional aviators, while others prefer to try their hand at flying without risking too much by settling with flight simulator games.

    Flight simulator games, also called airplane games, are fit for all ages who love flying. Such games offer a different kind of thrill, such that players who start very young tend to develop a liking for flying the real thing.

    iFlightSimulatorGames.com is an online resource that caters to enthusiasts and fans of flight simulator games. Featuring various airplane and helicopter flying games on Xbox, Playstation, Wii and even smartphones and iPads, the website offers information and useful reviews.

    iFlightSimulatorGames.com offers data about quite a number of games, including Space Shuttle Mission, Airmail on iPad, Combat Wings, Attack on Pearl Harbor, the Ultimate Flight Simulator Series, Sky Gambers, Bird of Steel, F-Sm Space Shuttle, Top Gun, AviNation, Aerosoft, Airbus Xtreme, Ace Combat: Fires Of Liberation, Strike Fighters, Bird of Steel, EX2 Flightsticks, X-Plane for iPad and ProFlightSimulator Flight Simulation.

    Blending fun and information, iFlightSimulatorGames.com provides tips on how to pick the best flight simulator games from among the many that are released each year. The website underscores that it is best to discover all games’ features, specs and system requirements, as they each have something different to offer and cater to different kinds of players.

    iFlightSimulatorGames.com notes that when it comes to playing flying games, gamers should not neglect knowing whether the game they choose actually runs on their computer.

    Making an investment in a new system is impractical, which is why the operating system should be watched out for. Needless to say, a flight simulator game that is designed for Windows might not have a version for Mac or Linux.

    To know more about games that involve aircraft flying, please visit http://www.iflightsimulatorgames.com for information.


    iFlightSimulatorGames.com is a new website that is dedicated to featuring the ins and outs of flight simulator gaming. The online resource caters to flight simulator gamers who need information about their favorite gaming hobby.

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      Online Blog Takes a Look at Fashion in Politics Around the Globe, and Publishes a List Titled ‘The 10 Best-Dressed Heads of State in 2012′

      San Francisco, Ca (PRWEB) October 29, 2012

      Cheap-Neckties.com, a well-known retailer focusing on discount mens ties and accessories, has just published their TOP 10 list titled “The 10 Best-Dressed Heads of State 2012″. The articles consist of ten individual pieces, each focusing on a specific head of state or government throughout the world. Dmitri Medvedev of Russia is awarded the top spot.

      With politics being in the forefront of just about everyones mind at the moment, we figured thered be no better time to take a look at the fashion and style of some of the better-known politicians throughout the world, says Hendrik Pohl, founder of Cheap-Neckties.com. After all, it can be quite easy to get wrapped up in the race for the white house and forget that were not the only country on this planet. Barack Obama and Mitt Romney are both rather stylish in their own ways, but there are plenty of other politicians in the world that deserve to be highlighted for the way they dress.

      Each article in this series serves to analyze key aspects of the style and fashion of ten of the best-dressed heads of state and government in the world. British prime minister David Cameron is highlighted for trademark blue ties and expert approach to wearing silver vests, for example, while China premier Wen Jiabao is given attention for his perfectly-tailored business suits and deep, bold ties. Heads of state and government in Russia, the United States, France and 5 other countries are also highlighted in their own pieces.

      A lot of these men are well-known, but some – Elio Di Rupo of Belgium, for example – are perhaps lesser known in countries such as America, says Pohl. Nevertheless, these are individuals who approach style and fashion in a way that clarifies just how important it is, and deserve to be highlighted as some of the best-dressed politicians in the world. Regardless of how one feels about the work theyve done in their leadership roles, its difficult to argue against the fact that these men certainly know how to dress well.

      Cheap-Neckties.com is well-known for publishing article series that focus on the fashion and style of politicians and celebrities. In the past, such topics as Best-Dressed GOP Candidates and Worst-Dressed Congressmen have been highlighted.

      The article series are all in good fun, of course, but theyre also meant to be educational, says Pohl. The more our readers can learn about how fashion and psychology combine in politics, the better informed theyll be.

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        ETech 7 Inc. Nine Elements of On-Page Website Optimization

        New York (PRWEB) October 30, 2012

        Optimising your site for better search rankings? Here are 9 tips for on-page optimization, fresh from ETech 7 Inc.s marketing team:

        1. Page Title

        This is one of the most important and simplest steps to take. They sit at the the browser window when you view a web page. They are also titles of a pages that appear in search engines. Make them descriptive, but also snappy and relevant to the rest of your site.

        2. Meta Description

        Meta data is the HTML description of a site inside a Google search. These tags may not influence search engine rankings, but they can draw in visitors.

        3. Headings

        It is good to include keywords in headings whenever possible. h1 tags give the text more weight as keywords than h2 tags, and h2 tags have more weight than h3 tags. h4 and h5 tags can be used as well, but their influence on keywords is virtually the same as that of regular text.

        4. Cascading Style Sheets (CSS)

        HTML is the back-end code of any website read by a search engine. While they extract relevant information from HTML, such as keywords, CSS hold a template for the layout of a page. In CSS, one can define how headings, links, and other visual elements of the text appear.

        5. Images

        Images on a web page can certainly enhance user experience. However, when inserting images into a website, keep in mind the following:

        Dont use images excessively. More pictures means the page will take longer to load. This has a negative impact both on user experience and SEO.

        Associate text with pictures. Search engines do not read images; they read only text– ALT text, to be precise. Use this HTML attribute with associated terms and phrases for better results.

        Include keywords in image file names. This will help draw in relevant traffic from image searches. Separate different keywords in the file name with a dash (-).

        6. Domain Information.

        Search engine rankings favor sites that are registered for a longer period of time. Longer domain registrations indicate a commitment to the site, which means that the site has a lower chance of being removed as spam. Extend the website registration for an extra year for an SEO boost.

        7. MOZ Rank

        MOZ Rank is a general measure of how much online reputation a site has. The higher the MOZ rank, the better. Note that MOZ Rank is an important factor in both on-page and off- page optimization. Consult the ETech 7 marketing team for more.

        8. Content is king!

        When Google scans, or crawls a site, it updates all the relevant information, such as keywords and other SEO data. The key to improved rankings is to attract these crawls and have them visit your site as often as possible.

        The best thing to do is to produce fresh content and publish it on the website regularly. Always remember: there is no substitute for fresh, relevant, well written copy. Quite simply, content is king!

        9. URL Structure

        The URL of a web page is its web address. For example, ETech 7 Inc.’s blog has a URL of http://blog.etech7.com/ The URL structure of a website is all about how the different URLs are interconnected. So link your pages in a way that streamlines use experience. Itll increase the flow of traffic to your site and boost your rankings.

        Happy optimizing!

        About the Company:

        ETech 7 Inc. is a technology services leader offering data backup and recovery, web development, networking solutions, search engine optimization and social media management. Please visit ETech7.com or contact (212) 997-1202 for more information.

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          Oceanhouse Media Launches Four Dr. Seuss Book Apps for Windows 8

          Encinitas, Calif. (PRWEB) October 30, 2012

          Leading app publisher Oceanhouse Media, Inc. today announced the release of four Dr. Seuss book apps for Windows 8. This marks the first time the company has developed book apps for PCs.

          The Dr. Seuss titles now available in the Windows Store include The Cat in the Hat, How the Grinch Stole Christmas!, The Lorax and One Fish Two Fish Red Fish Blue Fish. Ranging in price from $ 3.99 to $ 4.99, the book apps run on Windows 8 PCs and tablets, working well with both mouse and touch.

          Were thrilled to develop our award-winning Dr. Seuss book apps for Windows 8, said Michel Kripalani, president of Oceanhouse Media. Our book apps focus on helping children learn to read and the interactive features, such as word highlighting and picture/word association, truly enhance the reading experience.

          The book apps feature Dr. Seusss original text and illustrations combined with realistic sound effects, professional narration and custom background audio. In addition, individual words are highlighted as the story is read and words zoom up and are spoken when pictures are touched. A new page selector allows readers to easily turn to any page within each book app.

          The Dr. Seuss book apps from Oceanhouse Media reimagine the classic childrens books for Windows 8, said John Richards, senior director, Windows App Marketing for Microsoft Corp. They provide a rich and engaging experience for children and adults alike. The apps are also a great way to build a library of interactive books.

          Three reading options included are Auto Play (geared toward younger readers), which plays like a movie by automatically reading and turning pages; Read To Me, which allows users to listen to the narrated story with words highlighted as they are read; and Read It Myself, which lets users read the book in its traditional format.

          About Oceanhouse Media, Inc.

          Creators of the award-winning Dr. Seuss book apps, Oceanhouse Media, Inc. is a leading publisher of more than 250 mobile and desktop apps for iOS (iPhone

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            Filmed with iPhones and a Budget of $0, a New Horror Movie Franchise Begins

            (PRWEB) October 31, 2012

            The casting process occurred through an acting contest opened to the general public. The scenario for the short film was posted on the movie site along with instructions from the director.

            The contestants delivered their performance on You Tube using their iPhones and camera phones. On October 31st at midnight, the short film titled “iBetween” was unveiled on the official site.

            “iBetween” is the story of a mother whose four year old daughter mysteriously disappeared three weeks prior. One day, the mother receives video messages on her phone from complete strangers. Each individual leaving just a few words, speaking as if they were the little girl themselves.

            By piecing all of the messages together, she gathers the following overall message from these strangers: Mommy, I am trapped i-between, please help me I’m scared. As a last resort, the mother posts a video message on You Tube asking help from anyone who might be able to help her. She eventually gets a video response from a doctor offering his help. He claims that her little girl is in between dimensions. Between our world and death.

            “I would call it a modern day, digital far-cousin of “Poltergeist”. Since it’s a short film (under 4 minutes) it is setting up the story-line for a feature film to come, where people could continue to be part of the film and actually land a role from their home, by simply using their iPhone, if they have the skills that is. We had quite a bit of talent for this contest from all over the world. The bulk of the entries came from the U.S. but we also has several people submitting from Australia, U.K., South Africa and even India. Says Dom Adams the director/producer of the film. “I see it a little bit like the “American Idol” of acting, where unknown actors can show their acting talent and the public get to vote for their favorite performer, allowing them to actually see the very people they voted for in the final film.” Concludes Adams.

            You may visit the official site at http://iBetweenmovie.com.

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              TrainACE Adds White Papers to their Long List of Resources for their Customers

              Greenbelt, MD (PRWEB) November 05, 2012

              TrainACE, a leading and internationally recognized provider of IT training, has ramped up their resources yet again. About a year ago TrainACE brought free cyber security training webinars to the public and now white papers have joined the free resources provided by this leading training organization. These white papers are written by TrainACEs own staff and subject matter experts who have years of training and experience in the fields which they write about. Topics are chosen by researching the most relevant and up-to-date areas being talked about by IT professionals from all over the world. These important topics are then conceptualized and brought to industry professionals in easy to read, relevant, research style white papers.

              The first publicized white paper explores two advanced security certifications, CASP and CISSP. CompTIAs CASP exam is newly created and filled with the practical knowledge needed by cyber security professionals. Since it is so new, many people are still pondering over whom the exam is best fit for and how it can be strategically placed into the IT certification puzzle. This particular white paper, titled Examining the Notable Differences in CASP vs. CISSP, answers the questions many people have regarding the two certifications and explains how the exams actually work quite efficiently when paired hand-in-hand.

              Hot topic recommendations are currently being gathered by TrainACE for future papers. Be on the lookout for more topics to be added to the companys website, http://www.trainace.com/white-papers/, in the very near future.

              TrainACE is a renowned IT, IT security and Information Assurance training and certification leader. TrainACE has received multiple international awards from many respected professional organizations that have recognized their dedication and commitment to training excellence. TrainACE is known as one of the few training vendors in the world that produces custom, five day, hands-on information assurance and advanced security classes. Many of these classes of which can be further customized and fitted to better accommodate the specific training needs of any organization or objective. TrainACE has proudly been training IT professionals since 2001. For more information about their white papers, free training webinars and training classes, visit their website http://www.trainace.com

              Academy of Computer Education (TrainACE)

              Greenbelt, MD & Ashburn, VA


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                SKYCIG Electronic Cigarette Motor Star Tom Ingram Reveals Benefit of Sponsors’ Support as He Reflects on His 2012 Performance

                London, UK (PRWEB UK) 5 November 2012

                The High Wycombe-based speed demon tallied six victories, 17 podiums, four pole positions and six fastest laps en route to third spot in the Ginetta GT Supercup standings in 2012, and he was a contender for the crown right the way down to the season finale.

                There were several standout highlights, most notably the six triumphs registered by the 19-year-old British Racing Drivers Club Rising Star, MSA Academy member and KENNETT brand ambassador. The first of them came under sustained pressure at Donington Park, kick-starting his bid for the laurels, whilst there was another at Croft and peerless double-tops at Oulton Park in front of new sponsor SKYCIG and Rockingham. He rounded out the season with a rostrum finish in the torrential rain at Brands Hatch.

                Its been a mixed year, with a number of highs-and-lows, he mused. We had four DNFs that cost us dear, and theres a part of me that cant help but think, what if..? We lost 35 points at Snetterton, for example, when my engine blew up as I had a 1.5-second lead.

                On the positive side, though, we got quicker and quicker as the year progressed, and as we grew in confidence as a team, we consistently managed to extract more pace from the car; that was in large part thanks to the sterling efforts of all the boys at JHR Developments, who I truly cant thank enough.

                I also need to thank SKYCIG and Hansford Sensors for their incredible support. I regard Chris Hansford more as a friend now than anything else; he has a huge passion for motorsport, and enjoys nothing better than attending race meetings and really getting stuck in.

                Going back to Oulton Park, Ingrams dominant double victory could not in hindsight have come at a better time, as it was achieved just as energy drinks company KX was scouting out emerging talent for its new and exciting KX Akademy. With the spotlight shining down bright, the former Ginetta G50 Champion, Ginetta Junior Champion and British Karting Champion responded magnificently and he was duly selected as one of only two drivers to be inducted onto the prestigious programme.

                In every area, he affirms, the association has been invaluable, from no longer needing to fret over whether he can afford to make the next meeting to having the opportunity to tap into the expertise of the schemes mentor, two-time British Touring Car Champion Jason Plato.

                Having KXs support has been a tremendous boost, Ingram acknowledges, and I owe everybody there a massive thank you for believing in me. Financially, weve never been 100 per cent sure we would be able to finish the season before, so it was a huge weight off our minds in that respect. To not have to constantly worry about funding for the first time and being liberated to concentrate solely on the racing has been amazing it felt like a reward for all the hard work weve put in over the years.

                Ive been able to take more chances and drive the way I want to drive and with a decent budget behind us at last, I think we showed what we can do. I really hope we can continue the partnership next year; Ive benefitted so much from being a member of the KX Akademy, but theres still so much more I can learn.

                The training sessions on dealing with the media, sponsorship and finance and how best to market yourself have all been extremely valuable there wasnt a single one in which I didnt acquire something useful and having Jason as a mentor is something money cant buy. He has been there before and has the T-shirt to prove it, and theres no end of knowledge and advice that Ive been able to glean from his experience.

                It has been a pleasure to work with Tom this year, adds Plato, the respect palpably mutual. He is clearly a very gifted young racing driver who appears to have a bright future within the sport I just hope he doesnt become too good, too quickly, or else hell have me out of a job!

                In all seriousness, though, hes a very hard-working, intelligent and pleasant lad who listens and takes everything in, and his success over the past three seasons speaks for itself. I actually see quite a bit of myself in Tom from when I was his age, and wherever he races next year, I have no doubt he will acquit himself admirably.

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                  Les Miserables Tickets: Cheap Les Miserables Tickets for Chicago, Houston, Washington DC, Kansas City, Philadelphia, Pittsburgh, Charlotte and Denver Are Now Available

                  New York, NY (PRWEB) November 05, 2012

                  Cheap Concert Tickets reports that sales for Les Miserables tickets in Chicago, Houston, Washington DC and Kansas City are brisk. This site is offering a customer appreciation discount code for any Les Miserables ticket purchase. Add code LES-MISERABLES at the checkout for special savings on any order.

                  Les Miserables is a popular Broadway musical which was introduced in 1980. Originally, Les Miserables was done in the French language. The idea for the play was given by Alain Boublil and it was based on the novel “Les Miserables” by Victor Hugo. Claude-Michel Sch

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                    Nene Musik Re-Signs Pop / Latin Tropical Sensation Brenda K. Starr

                    Port St. Lucie, FL (PRWEB) November 06, 2012

                    When you think of soulful pop voices of the late 80s, Brenda K. Starr is one on top of radio stations and DJs lists. Brendas hits include the Grammy Award-nominated and #1 pop ballad; “I Still Believe,” and the club/dance smash, “What You See is What You Get.” I Still Believe became one of the top ballads of the late 80s placing Brenda on several Billboard charts. The song was later re-recorded and turned into another chart-topping hit, once more, by one of Brenda’s former back-up singers turned international superstar, Mariah Carey. As a matter of fact, at the same time that Carey was working as a vocalist for her, Brenda was developing quite a name for herself in both the Pop and Salsa musical worlds. Mariah Carey paid homage to her, acknowledging Brenda as one of her mentors on the mega-selling video, Mariah Carey: Around The World.

                    Brenda has also been internationally recognized as a leader in the Latin music explosion for many years, earning her the title, “La Diva de Salsa.” Her first Spanish album release, “Te Sigo Esperando”, was certificated Gold by the RIAA. It was followed by four more Spanish albums, entitled “No Lo Voy A Olvidar”, “Petalos de Fuego”, the critically-acclaimed, “Temptation” and “Atrevete a Olvidarme” which fittingly translated to: “I Dare You to Forget Me.” In 2002, the Temptation album garnered two Latin Billboard Awards: Hot Latin Track of the Year-Vocal Duo and Tropical /Salsa Airplay Track of the Year-Female. Standouts have included her collaborations with internationally acclaimed crooners like Victor Manuelle and Tito Nieves.

                    Nene Musik and Its team is excited to be working with Brenda again. Brenda is a true inspiration for many up and coming artists. She commands the stage with lots of energy. Our clients are already requesting dates for her next tour, says Ruben Martinez (Chairman & CEO of Nene Musik). Nene Musik will also assist Brenda in working with new producers for a 2013 release.

                    About Nene Musik Productions, Llc.

                    Nene Musik Productions, Llc. (http://www.nenemusik.com) was established in 1989. Today, It is a boutique Artist Management and Consulting Agency that services Recording Artists, International DJ’s and celebrities that have been misrepresented by others in their past. Dennis Rodman, Cascada, Mia Martina and Tora from X Factor are just of few on Nene Musik’s Client Roster. Nene Musik’s experience and commitment to excellence have earned them the reputation as one of the best Artist Management / Consulting companies in the World.

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